IL-10 -1082 SNP and IL-10 in primary CNS and vitreoretinal lymphomas
Graefe's Archive for Clinical and Experimental Ophthalmology, 06/01/2012
Ramkumar HL et al. – Primary vitreoretinal lymphoma (PVRL) and primary central nervous system lymphoma (PCNSL) patients had similar IL–10 –1082 A allele frequencies, but genotype distributions differed from healthy controls. The findings suggest that the IL–10 –1082 A allele is a risk factor for higher IL–10 levels in PVRLs and PCNSLs. Higher IL–10 levels have been correlated with more aggressive disease in both PVRLs and PCNSLs, making this finding an important and potentially clinically significant observation.