Immunopathogenesis of Graves ophthalmopathy: The role of the TSH receptor

Best Practice & Research Clinical Endocrinology & Metabolism, 06/08/2012

Recent studies from several laboratories have shown that thyrotropin receptor activation in orbital fibroblasts enhances hyaluronic acid synthesis and adipogenesis, both cellular functions that appear to be upregulated in the diseased orbit. The phosphoinositide 3–kinase/Akt signaling cascade, along with other effector pathways including adenylyl cyclase/cAMP, appears to mediate these processes.

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