New anticoagulant drugs for treatment of venous thromboembolism and stroke prevention in atrial fibrillation
Journal of Internal Medicine, 06/01/2012
Tripodi A et al. – Venous thromboembolism and atrial fibrillation are common conditions in Western countries. The mainstay of treatment and prevention for these diseases is fast–acting anticoagulant drugs such as heparins and vitamin K antagonists. The use of these drugs is, however, complex and demanding for both patients and physicians. Recently, new antithrombotic drugs that act directly by inhibiting activated coagulation factors such as factor X or thrombin have been developed and investigated in phase III clinical trials.