Residues within the c-terminal arm of the herpes simplex virus 1 glycoprotein b ectodomain contribute to its refolding during the fusion step of virus entry
Journal of Virology, 06/13/2012
Connolly SA et al. – Authors propose that the formation of the coil–arm complex drives the gB transition to a postfusion conformation and the coil–arm complex performs a function similar to that of the six–helix bundle in class I fusion. Furthermore, we suggest that these specific mutations in the arm may energetically favor the prefusion state of gB.