Diabetes and Lung Cancer Among Postmenopausal Women
Diabetes Care, 05/30/2012
Luo J et al. – Postmenopausal women with treated diabetes, especially those using insulin, have a significantly higher risk of lung cancer. The influence of diabetes severity and specific classes of therapy for diabetes on lung cancer risk require future study.Methods
- Postmenopausal women (n = 145,765), ages 50–79 years, including 8,154 women with diabetes at study entry were followed for a mean of 11 years with 2,257 lung cancers diagnosed.
- Information on diabetes therapy was collected via two methods (self–reported information on treatment history collected on a questionnaire at baseline and a face–to–face review of current medication containers that participants brought to the baseline visit).
- Lung cancers were confirmed by central medical record and pathology report review.
- Cox proportional hazards regression models adjusted for lung cancer risk factors were used to estimate hazard ratios (HRs) (95% CI) for diagnosis of diabetes and treatment of disease as risk factors for lung cancer.
- Compared with women without diabetes, women with self–reported treated diabetes had a significantly higher risk of lung cancer (HR 1.27 [95% CI 1.02–1.59]), with risks increasing for women with diabetes requiring insulin treatment (1.71 [1.15–2.53]).
- However, the authors did not observe a significant association between lung cancer risk and diabetes not treated with medication or with duration of diabetes.