Alcoholism worsens the survival of patients with hepatitis B virus and C virus-related hepatocellular carcinoma
Hepatology International,  Clinical Article

Lee YH et al. – Alcoholism in patients with hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is characterized by early development of hepatocellular carcinoma (HCC) with advanced cirrhosis and cancer staging at diagnosis. Alcoholism independently predicts an increased risk of mortality in patients with HBV– and HCV–related HCC.

Methods
  • A total of 1,888 patients were retrospectively investigated and categorized into six groups, HBV only (n=977), HBV with alcoholism (n=197), HCV only (n=544), HCV with alcoholism (n=67), dual HBV and HCV (n=82), and dual virus with alcoholism (n=21), to examine their interactions on the outcome.

Results
  • Compared to their counterparts, alcoholic patients coinfected with HBV and/or HCV tended to be younger, had higher male–to–female ratios, worse performance status, more severe liver cirrhosis, advanced cancer staging, and tumor burden than patients without alcoholism.
  • In survival analysis, patients with HBV with alcoholism had a significantly decreased survival than the HBV–only group (p=0.001).
  • A shortened survival was also observed in HCV with alcoholism group compared to the HCV–only group (p=0.011).
  • Dual virus infection with alcoholism did not significantly worsen the survival compared to the dual virus infection group.
  • In the Cox proportional hazards model, HBV with alcoholism group [risk ratio (RR) 1.299, p=0.032] and HCV with alcoholism (RR 1.523, p=0.025) group were independent predictors associated with decreased survival compared to their counterpart of HBV– and HCV–only groups.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

1 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

2 Association of Coffee Consumption With All-Cause and Cardiovascular Disease Mortality Mayo Clinic Proceedings, September 19, 2013    Evidence Based Medicine    Clinical Article

3 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

4 Chocolate intake and diabetes risk Clinical Nutrition, July 21, 2014    Clinical Article

5 High protein weight loss diets in obese subjects with type 2 diabetes mellitus Nutrition, Metabolism & Cardiovascular Diseases, January 3, 2014    Clinical Article

6 Pathology residency training: time for a new paradigm Human Pathology, March 25, 2014    Clinical Article

7 Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth Obstetrics and Gynecology, July 3, 2014    Clinical Article

8 Anemia in the elderly Current Opinion in Hematology, November 12, 2012

9 Risk of dementia after anaesthesia and surgery The British Journal of Psychiatry, March 4, 2014    Clinical Article

10 Coffee consumption and risk of prostate cancer: A meta-analysis of prospective cohort studies Carcinogenesis, January 2, 2014    Evidence Based Medicine    Review Article    Clinical Article

11 Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease Clinical Nutrition, July 22, 2014    Clinical Article

12 Drug-induced long QT in adult psychiatric inpatients: The 5-year cross-sectional ECG screening outcome in psychiatry study American Journal of Psychiatry, December 11, 2013    Clinical Article

13 Dietary protein and muscle in older persons Current Opinion in Clinical Nutrition & Metabolic Care, December 24, 2013    Review Article

14 Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives The Lancet, June 20, 2014    Review Article    Clinical Article

15 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 15, 2014    Clinical Article

16 Role of herbal medicines in cardiovascular diseases Full Text Middle East Journal of Family Medicine, December 18, 2013    Free full text    Review Article
Exclusive Author Commentary

17 Nuts in the prevention and treatment of metabolic syndrome American Journal of Clinical Nutrition, June 5, 2014    Review Article

18 Virtual reality training helps adults with autism prepare for job interviews Northwestern University Feinberg School of Medicine News, May 15, 2014

19 Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years Full Text Pediatrics, July 12, 2013    Free full text    Clinical Article

20 Possible association between vitamin D deficiency and restless legs syndrome Full Text Neuropsychiatric Disease and Treatment, June 6, 2014    Free full text    Clinical Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close