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Nav1.7-related small fiber neuropathy
Neurology, 06/12/2012
Han C et al. – The observations provide support, from a patient with biopsy–confirmed small fiber neuropathy (SFN), for the suggestion that functional variants of Nav1.7 that impair slow–inactivation can produce DRG neuron hyperexcitability that contributes to pain in SFN. Nav1.7 channelopathy–associated SFN should be considered in the differential diagnosis of cases of SFN in which no other cause is found.
