In vitro efficacy of the combination of voriconazole and anidulafungin against voriconazole-resistant cyp51A mutants of Aspergillus fumigatus
Diagnostic Microbiology and Infectious Disease, 06/01/2012
Krishnan–Natesan S et al. – The combination of VCZ and anidulafungin was synergistic (FICI <0.5) not only against VCZ–susceptible isolates, but also against 8 of 10 VCZ–R, G448S mutants of A. fumigatus. The combination demonstrated synergy against the VCZ–R clinical isolate as well.