Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis
The Knee, 05/18/2012
Koh YG et al. – The short–term results of the study are encouraging and demonstrate that infrapatellar fat pad–derived mesenchymal stem cell (MSC) therapy with intraarticular injections is safe, and provides assistance in reducing pain and improving function in patients with knee osteoarthritis.Methods
- Twenty five stem cell injections combined with arthroscopic debridement were administered to patients with knee OA.
- A mean of 1.89×106 stem cells were prepared with approximately 3.0mL of platelet–rich plasma (PRP) and injected in the selected knees of patients in the study group.
- The mean Lysholm, Tegner activity scale, and VAS scores of patients in the study group improved significantly by the last follow–up visit.
- No major adverse events related to the injections were observed during the treatment and follow–up periods.
- The results were compared between the study and control groups, in which the patients had undergone arthroscopic debridement and PRP injection without stem cells.
- Although the preoperative mean Lysholm, Tegner activity scale, and VAS scores of the study group were significantly poorer than those of the control group, the clinical results at the last follow–up visit were similar and not significantly different between the two groups.