Transcription factor Efg1 contributes to the tolerance of Candida albicans biofilms against antifungal agents in vitro and in vivo

Journal of Medical Microbiology, 05/16/2012

The increased sensitivity to miconazole was, at least, partly due to an increased accumulation of miconazole in the cells as compared to wild–type or reintegrant Δefg1(EFG1) sessile cells. By using a rat biofilm model, authors further confirmed the role of Efg1 in the tolerance of C. albicans biofilms to miconazole when grown in vivo.

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