Comparison of the Therapeutic Efficacy of a Fixed Low-Dose Combination of Cinnarizine and Dimenhydrinate with Betahistine in Vestibular Neuritis: A Randomized, Double-Blind, Non-Inferiority Study
Clinical Drug Investigation, 05/21/2012
Scholtz AW et al. – The results showed that the fixed low–dose combination of cinnarizine and dimenhydrinate is an effective and well tolerated option for symptomatic treatment in unilateral Vestibular neuritis. The fixed combination led to significant improvements in vertigo and activities of daily living within the first week, and to a nearly complete recovery after 4 weeks. Neurotological testing revealed no signs of a possible detrimental influence of the 4–week treatment with the fixed combination compared with betahistine in terms of recovery of caloric responsiveness and abatement of rotation–induced nystagmus.