Use of propofol in pediatric intensive care units
Pediatric Critical Care, 05/18/2012
Kruessell MA et al. – This study shows that propofol is used off–license by many pediatric intensive care units in Ge. The majority of users has adopted tightly controlled regimens for propofol sedation, and limits the dose to ≤3–4mg/kg/hr and the maximum application time to 24–48 hrs.Methods
- The authors performed a nationwide survey.
- The questionnaire assessed the intensive care unit type, patient numbers, dosing, duration, age and time limits, indications, side effects, and institutional protocols for propofol usage.
- Questionnaire about routine use of propofol sent to 214 pediatric departments.
- One hundred ninety-four questionnaires (90.7%) were returned, ten had to be censored.
- The final analysis comprised 184 questionnaires (134 pediatric/neonatal intensive care units, 28 pediatric intensive care units, 22 neonatal intensive care units).
- Seventy-nine percent of intensive care units (n=145 of 184) used propofol in children under the age of 16yrs.
- Of these, 98% were for bolus application (n=142 of 145), 78% for infusion ≥3hrs (n=113 of 145), and 33% for infusion >3hrs (n=48 of 145).
- A lower age limit was applied by 52% (n=75 of 145) and a dose limit by 51% (n=74 of 145).
- The median dose limit was 4mg/kg/hr; 48% (n=70 of 145) used 3mg/kg/hr or less.
- A time limit was applied by 98% (n=46 of 47), 70% (n=33 of 47) used it for ≤24hrs, and 30% (n=15 of 47) for >24hrs.