Current standard treatments are ineffective, poorly tolerated or inappropriate in some patients, which had promoted the development of new therapies.
- Gout is caused by chronic hyperuricaemia and the formation of pro–inflammatory monosodium urate crystals in the joints.
- Pain associated with acute gout flares is treated with anti–inflammatories (e.g. NSAIDs, colchicine and corticosteroids).
- Chronic gout is managed with urate–lowering therapies (e.g. xanthine oxidase inhibitors).