Duodenal Expression of Toll-Like Receptors and Interleukins Are Increased in Both Children and Adult Celiac Patients
Digestive Diseases and Sciences, 05/30/2012
Eiro N et al. – TLR4 expression is associated with celiac disease (CD) independently of age at diagnosis. Pediatric patients and adult patients have a similar inflammatory profile, making it possible to treat both with the same immunological therapy in the future.Methods
- The expression levels of TLR3, TLR4, and TLR7, interleukins, and different transcription factors were analyzed on duodenal biopsies from ten children and 31 adults with CD, and 21 duodenal controls biopsies without CD (ten children and 11 adults).
- The analyses were performed by immunohistochemistry and real-time PCR.
- There were no significant differences in the studied parameters between adults and children.
- TLR4 expression level was increased twofold in CD specimens compared to controls.
- CD patients with high levels of TLR4 also showed high levels of interleukins (IL1, IL6, IL8, and IL17) as well as transcription factors (IRAK4, MyD88, and NF-κB).