Abnormal amygdala connectivity in patients with primary insomnia: Evidence from resting state fMRI

European Journal of Radiology, 05/10/2012

The decreased functional connectivity between the amygdala and insula, striatum, and thalamus suggests that dysfunction in the emotional circuit might contribute to the neurobiological mechanisms underlying primary insomnia (PI). The increased functional connectivity of the amygdala with the premotor and sensorimotor cortex demonstrates a compensatory mechanism to overcome the negative effects of sleep deficits and maintain the psychomotor performances in PI patients.

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