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Antioxidant supplementation in pregnant women with low antioxidant status
Journal of Obstetrics and Gynaecology Research, 05/16/2012
Wibowo NW et al. – Supplementation of women with low antioxidant status with micronutrients containing antioxidants during early gestation might reduce the risk of pre–eclampsia.
Methods- This study was a randomized, placebo–controlled trial of 8–12 weeks' pregnant women who had low antioxidant status treated with either antioxidants or control diets daily until 2 weeks' postpartum.
- The primary end–point was the risk of pre–eclampsia and the secondary end–point was the changes of angiogenic and anti–oxidant mRNA markers related to the outcome.
- There were 110 women enrolled in the study, randomly assigned to the supplementation (n = 52) and control group (n = 58).
- The overall rate of pre–eclampsia was 8.7% (nine subjects).
- There were significant differences (P = 0.034) between the supplementation and control group in the incidence of pre–eclampsia (2.0% [one case] and 14.5% [eight cases], respectively) and mRNA level of superoxide–dismutase, heme oxygenase–1, vascular endothelial growth factor receptor–1, endoglin and placental growth factor after supplementation.
