Effect of Vitamin D Repletion on Urinary Calcium Excretion among Kidney Stone Formers
Clinical Journal of the American Society of Nephrology, 05/17/2012
Exclusive author commentary
Leaf DE et al. – Among stone formers with vitamin D deficiency, a limited course of vitamin D repletion does not seem to increase mean urinary calcium excretion, although a subset of individuals may have an increase. These data suggest that vitamin D therapy, if indicated, should not be withheld solely on the basis of stone disease, but 24–hour urinary calcium excretion should be monitored after repletion.
Dr. David E. Leaf (05/20/2012) comments:
Our study suggests that vitamin D therapy should not be withheld from stone formers simply on the basis of hypercalciuria and a history of stones. However, a subset of individuals did indeed have an increase in urine calcium excretion, suggesting that a follow-up 24hr urine calcium measurement may be warranted to ensure safety.