MicroRNAs in Rheumatoid Arthritis: Potential Role in Diagnosis and Therapy
Filkova M et al. – Over the past several years it has become clear that alterations exist in the expression of miRNAs in patients with Rheumatoid Arthritis (RA). Increasing numbers of studies have shown that dysregulation of miRNAs in peripheral blood mononuclear cells or isolated T lymphocytes, in synovial tissue and synovial fibroblasts that are considered key effector cells in joint destruction, contributes to inflammation, degradation of extracellular matrix and invasive behaviour of resident cells. Thereby, miRNAs maintain the pathophysiological process typical of RA.