In routine UK hospital practice T-SPOT.TB is useful in some patients with a modest pre-test probability of active tuberculosis
European Journal of Internal Medicine , 05/09/2012
Turtle L et al. – Although it can add weight to a clinical diagnosis, T–SPOT.TB assay is not reliable for the diagnosis of active tuberculosis in a real world setting where the test is often used in patients with smear negative or extra–pulmonary disease. The test is useful for ruling out disease in HIV negative patients.