Discrepant Expression of MicroRNAs in Transparent and Cataractous Human Lenses
Investigative Ophthalmology & Visual Science, 05/18/2012
Wu C et al. – The authors report for the first time the distinct expression profiles of microRNAs (miRNAs) in the central epithelium of transparent and age–related cataractous human lenses. Significant differences in miRNA expression were identified, and the genes targeted by the relevant miRNAs were predicted. The differential expression of miRNAs suggests that these miRNAs have potential roles in lens development and/or cataract formation.