Cold ischaemia, innate immunity and deterioration of the glomerular filtration barrier in antibody-mediated acute rejection
Nephrology Dialysis Transplantation, 05/09/2012
Ripoll E et al. – Initial cold ischaemia (CI) increased the ColIV deposition in capillary glomerular basement membranes (CapBM), damaging the glomerular filtration barrier (GFB) and being responsible for part of the proteinuria associated with late allograft dysfunction. This deterioration of the GFB is related to the early innate immunity activation and subsequent up–regulation of CD40 in acute rejected grafts. In chronic rejected allografts, thickened CapBM may be a consequence of an unresolved immune–inflammatory response worsened by CI.