mdlinx mdlinx
Latest (476) Full Text Articles (11295) Article Summary

Transient Defect in Nitric Oxide Generation after Rupture of Fetal Membranes and Responsiveness to Inhaled Nitric Oxide in Very Preterm Infants with Hypoxic Respiratory Failure
The Journal of Pediatrics,

Aikio O et al. – Seven percent of VLGA infants with preterm rupture of membranes and 15% of those with prolonged preterm rupture of membranes (PPROM) developed hypoxic respiratory failure (HRF), characterized by pulmonary hypertension that acutely responds to iNO. These infants may have a transient deficiency in the inflammatory response, including a defect in nitric oxide generation in airspaces.

Methods
  • Of a cohort of 765 VLGA infants, 144 required mechanical ventilation.
  • Airway specimens from these patients were prospectively studied.
  • Infants who developed HRF (oxygenation index >25) with echocardiographic diagnosis of pulmonary hypertension were treated with inhaled nitric oxide (iNO).
  • Three gestation comparison groups were formed on the basis of specific antenatal complications: prolonged preterm rupture of membranes (PPROM), spontaneous preterm birth, and preeclampsia.

Results
  • Seventeen (2.2% of all VLGA infants) developed HRF.
  • In all 17 cases, PPROM complicated the antenatal course; these infants responded to iNO, regardless of infection or PPROM.
  • The chest radiographs of HRF and non-HRF PPROM infants were similar.
  • Airway proinflammatory cytokines and nitrite + nitrate levels were low in infants with HRF, but they increased during iNO treatment and remained elevated after discontinuation of iNO.
  • Each of the 3 comparison groups had different and characteristic patterns of airway cytokines and nitrite + nitrate levels.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

Last month's top read Top Articles of 2013

1 Association of violence with emergence of persecutory delusions in untreated schizophrenia American Journal of Psychiatry, March 4, 2014    Clinical Article

2 Glycation of apolipoprotein C1 impairs its CETP inhibitory property: pathophysiological relevance in patients with type 1 and type 2 diabetes Diabetes Care, March 4, 2014    Clinical Article

3 Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn's disease Clinical Gastroenterology and Hepatology , March 4, 2014    Clinical Article

4 CHIP regulates osteoclast formation through promoting TRAF6 protein degradation Arthritis & Rheumatism, March 5, 2014    Clinical Article

5 Dietary carrot consumption and the risk of prostate cancer European Journal of Nutrition, February 17, 2014    Clinical Article

6 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

7 Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation Journal of Clinical Oncology, March 4, 2014    Clinical Article

8 Risk of dementia after anaesthesia and surgery The British Journal of Psychiatry, March 4, 2014    Clinical Article

9 Vitamin D deficiency and hypocalcemia in an infant with newly diagnosed AML Journal of Pediatric Hematology/Oncology, March 5, 2014

10 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

11 Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 4, 2014    Clinical Article

12 Endoscopic characterization of sessile serrated adenomas/polyps with and without dysplasia Endoscopy, March 4, 2014    Clinical Article

13 Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 4, 2014    Clinical Article

14 Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality British Journal of Anesthesia, March 27, 2014    Review Article

15 Tea consumption and the risk of five major cancers: A dose-response meta-analysis of prospective studies Full Text BMC Cancer, March 18, 2014    Free full text    Evidence Based Medicine    Review Article

16 Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a mendelian randomization study Diabetes, March 4, 2014    Evidence Based Medicine    Clinical Article

17 Scientists reveal new findings for reversing early and late atherosclerosis The Mount Sinai Hospital, March 10, 2014

18 Yogurt consumption and impact on health: focus on children and cardiometabolic risk American Journal of Clinical Nutrition, March 21, 2014    Review Article

19 Molecular subtyping of metastatic renal cell carcinoma: implications for targeted therapy Full Text Molecular Cancer, March 5, 2014    Free full text    Clinical Article

20 Rare coding variants and breast cancer risk: Evaluation of susceptibility loci identified in genome-wide association studies Cancer Epidemiology, Biomarkers & Prevention, March 4, 2014    Clinical Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Other Topics in Medical Student

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close