Immunogenicity and Cross-Reactivity of a Representative Ancestral Sequence in Hepatitis C Virus Infection Full Text
The Journal of Immunology, 05/04/2012
Burke KP et al. – CD8+ T cells expanded with representative sequence hepatitis C virus (HCV) generally more broadly and robustly recognized highly diverse circulating HCV strains than did T cells expanded with either consensus sequence or naturally occurring sequence variants. These data support the use of representative sequence in HCV vaccine design.