Role of genetic polymorphisms of the dopaminergic system in Parkinsons disease patients with impulse control disorders
Parkinsonism & Related Disorders, 06/01/2012
Vallelunga A et al. – In the study, there were no differences in the frequency of variant of dopamine D2 receptors (DRD2) Taq1A, COMT and DAT1 between the two groups. Polymorphisms of dopaminergic genes do not play a relevant role in the development of impulse control disorders (ICDs) in Parkinson’s disease (PD) suggesting that ICD originate from inability to filter inappropriate behaviors triggered by dopaminergic therapy.