Proteolytic activation of proapoptotic kinase protein kinase Cdelta by tumor necrosis factor alpha death receptor signaling in dopaminergic neurons during neuroinflammation
Journal of Neuroinflammation, 05/10/2012
Gordon R et al. – The results identify proteolytic activation of protein kinase Cdelta (PKCdelta) proapoptotic signaling as a key downstream effector of dopaminergic cell death induced by Tumor necrosis factor alpha (TNF). These findings also provide a rationale for therapeutically targeting PKCdelta to mitigate progressive dopaminergic degeneration resulting from chronic neuroinflammatory processes.