Lidocaine time- and dose-dependently demethylates deoxyribonucleic acid in breast cancer cell lines in vitro Full Text
British Journal of Anesthesia, 05/03/2012
Lirk P et al. – The findings suggest that demethylating tumour–suppressive effects of anaesthetic interventions may only be detectable in specific types of cancer due to differential methylation profiles. At clinically relevant concentrations, lidocaine demethylates DNA of breast cancer cell lines in vitro.