Prevalence and correlates of antipsychotic polypharmacy: A systematic review and meta-regression of global and regional trends from the 1970s to 2009
Schizophrenia Research,  Evidence Based Medicine

Gallego JA et al. – Antipsychotic polypharmacy (APP) is common with different rates and time trends by region over the last four decades. APP is associated with greater anticholinergic requirement, shorter observation time, greater illness severity and lower antidepressant use.

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