Dietary fructose, carbohydrates, glycemic indices and pancreatic cancer risk: a systematic review and meta-analysis of cohort studies
Annals of Oncology,  Evidence Based Medicine  Clinical Article

Aune D et al. – This meta–analysis does not support an association between diets high in glycemic index, glycemic load, total carbohydrates or sucrose and pancreatic cancer risk. The finding of an increased risk with fructose intake warrants further investigation in studies with better adjustment for confounding and in non–American populations.

Methods
  • PubMed and several other databases were searched for prospective studies of intake of carbohydrates, glycemic index and glycemic load and pancreatic cancer up to September 2011.
  • Summary relative risks were estimated using a random effects model.

Results
  • Ten cohort studies (13 publications) were included in the meta-analysis.
  • The summary relative risk (RR) per 10glycemic index units was 1.02 [95% confidence interval (CI): 0.93-1.12, I2=0%], per 50glycemic load units was 1.03 (95% CI: 0.93-1.14, I2=10%), per 100g/day of total carbohydrates was 0.97 (95% CI: 0.81-1.16, I2=35%), and per 25g/day of sucrose intake was 1.05 (95% CI: 0.85-1.23, I2=53%).
  • A positive association was observed with fructose intake, summary RR=1.22 (95% CI: 1.08-1.37, I2=0%) per 25g/day.

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