Early Administration of Low-Dose Aspirin for the Prevention of Preterm and Term Preeclampsia: A Systematic Review and Meta-Analysis
Fetal Diagnosis and Therapy,  Clinical Article

Roberge S et al. – Low–dose aspirin administrated at or before 16 weeks of gestation reduces the risk of preterm but not term preeclampsia.

Methods
  • A systematic review and meta–analysis of randomized controlled trials were performed.
  • Women who were randomized to low–dose aspirin or placebo/no treatment at or before 16 weeks of gestation were included.
  • The outcomes of interest were preterm preeclampsia (delivery <37 weeks) and term preeclampsia.
  • Pooled relative risks (RR) with their 95% confidence intervals (CI) were computed.

Results
  • The search identified 7,941 citations but only five trials on a combined total of 556 women fulfilled the inclusion criteria.
  • When compared to controls, aspirin initiated ≤16 weeks of gestation was associated with a major reduction of the risk of preterm preeclampsia (RR 0.11, 95% CI 0.04–0.33) but had no significant effect on term preeclampsia (RR 0.98, 95% CI 0.42–2.33).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

<

Most Popular Medical Student Articles

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Make smarter career moves with less time.

Sign up for our free job placement service today and have a dedicated career consultant help locate the right physician job for you!
Click Here for more information.

Get Started Now!

Free-of-charge, no obligation.

Terms and Conditions For M3 Career Consult

By registering with the M3 Career Consult service you authorize M3 USA Corporation to represent you in your job search. The following is a summary of the terms of our service and our mutual obligations to help you find a job:

  • You designate M3 to act as your agent and represent you in your job search;
  • You will not pay us for this service
  • You will advise us of any companies or positions to which you apply or have applied;
  • You will advise us if you believe you are not capable of performing a position for which we submit you, or for which you interview;
  • You will keep all information we provide you about companies or positions strictly confidential;
  • You will promptly provide us with information we request of you;
  • You will make yourself reasonably available for phone, video and in-person conversations and interviews;
  • You will be truthful in all of your communications with us; and
  • You will advise us if anything above changes.
 

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List