mdlinx mdlinx
Latest (498) Full Text Articles (11295) Article Summary

Results of a phase II study of sirolimus and cyclophosphamide in patients with advanced sarcoma
European Journal of Cancer,  Clinical Article

Schuetze SM et al. – Sirolimus and cyclophosphamide were tolerated by the majority of patients. About 20% of patients had stable sarcoma for at least 6months but objective tumour response was infrequent.

Methods
  • Patients received 4mg sirolimus daily and 200mg cyclophosphamide d1-7 and 15-21 every 28days.
  • The primary objective was to estimate the 24-week PFS rate with a target of 25%.
  • Patients were followed for World Health Organisation (WHO) criteria tumour response by imaging every 8weeks.
  • Serum levels of sirolimus, lipids and vascular endothelial growth factor were measured.
  • Tumour tissue was analysed for mTOR, S6 ribosomal protein and cytochrome P450 3A4/5 by quantitative immunofluorescence.

Results
  • Forty-nine eligible patients were enrolled from September 2008 to December 2009.
  • Patients received a median of four cycles of therapy.
  • Starting doses of drugs were tolerated in 79%.
  • One patient achieved partial tumour response, 10 were progression-free for 24weeks and two completed 12 cycles of treatment.
  • Median PFS and overall survival (OS) were 3.4 and 9.9months, respectively.
  • Serious adverse events attributed to therapy occurred in 11% and included infection, pneumonitis and thrombosis.
  • Hypertriglyceridaemia from treatment and lower tumour phosphorylated-mTOR are associated with longer survival.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

Last month's top read Top Articles of 2013

1 Association of violence with emergence of persecutory delusions in untreated schizophrenia American Journal of Psychiatry, March 4, 2014    Clinical Article

2 Glycation of apolipoprotein C1 impairs its CETP inhibitory property: pathophysiological relevance in patients with type 1 and type 2 diabetes Diabetes Care, March 4, 2014    Clinical Article

3 Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn's disease Clinical Gastroenterology and Hepatology , March 4, 2014    Clinical Article

4 CHIP regulates osteoclast formation through promoting TRAF6 protein degradation Arthritis & Rheumatism, March 5, 2014    Clinical Article

5 Dietary carrot consumption and the risk of prostate cancer European Journal of Nutrition, February 17, 2014    Clinical Article

6 Egg consumption and risk of GI neoplasms: dose–response meta-analysis and systematic review European Journal of Nutrition, February 6, 2014    Evidence Based Medicine    Review Article

7 Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation Journal of Clinical Oncology, March 4, 2014    Clinical Article

8 Risk of dementia after anaesthesia and surgery The British Journal of Psychiatry, March 4, 2014    Clinical Article

9 Vitamin D deficiency and hypocalcemia in an infant with newly diagnosed AML Journal of Pediatric Hematology/Oncology, March 5, 2014

10 Long-term coffee consumption and risk of cardiovascular disease Circulation, February 11, 2014    Evidence Based Medicine    Review Article    Clinical Article

11 Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 4, 2014    Clinical Article

12 Endoscopic characterization of sessile serrated adenomas/polyps with and without dysplasia Endoscopy, March 4, 2014    Clinical Article

13 Insulin pump use in pregnancy is associated with lower HbA1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes Diabetologia - Clinical and Experimental Diabetes and Metabolism, March 4, 2014    Clinical Article

14 Low intraoperative tidal volume ventilation with minimal PEEP is associated with increased mortality British Journal of Anesthesia, March 27, 2014    Review Article

15 Tea consumption and the risk of five major cancers: A dose-response meta-analysis of prospective studies Full Text BMC Cancer, March 18, 2014    Free full text    Evidence Based Medicine    Review Article

16 Evidence for a causal relationship between early exocrine pancreatic disease and cystic fibrosis-related diabetes: a mendelian randomization study Diabetes, March 4, 2014    Evidence Based Medicine    Clinical Article

17 Scientists reveal new findings for reversing early and late atherosclerosis The Mount Sinai Hospital, March 10, 2014

18 Yogurt consumption and impact on health: focus on children and cardiometabolic risk American Journal of Clinical Nutrition, March 21, 2014    Review Article

19 Molecular subtyping of metastatic renal cell carcinoma: implications for targeted therapy Full Text Molecular Cancer, March 5, 2014    Free full text    Clinical Article

20 Rare coding variants and breast cancer risk: Evaluation of susceptibility loci identified in genome-wide association studies Cancer Epidemiology, Biomarkers & Prevention, March 4, 2014    Clinical Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Other Topics in Medical Student

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close