HTLV-I virological and histopathological analysis in two cases of anti-centromere-antibody-seropositive Sjogrens syndrome
Modern Rheumatology,

Nakamura H et al. – A high HTLV–I viral load in situ is supposed to promote the production of cytokines, especially TGF–β, resulting in the fibrous change of labial salivary gland (LSG) in anti–centromere–antibody (ACA)–seropositive Sjögren’s syndrome (SS) patients.

Methods
  • One patient was an HTLV–I carrier whereas the other was diagnosed with HTLV–I–associated myelopathy (HAM).
  • Background data including serum HTLV–I titers, viral loads, and cytokine profiles were recorded.
  • Azocarmine with aniline blue (Azan)–Mallory staining and immunohistochemistry of the labial salivary glands (LSGs) and a muscle biopsy specimen from the HAM patient were performed.

Results
  • Serum transforming growth factor beta (TGF–β), tumor necrosis factor alpha (TNF–α), and HTLV–I viral load were high in the HAM–SS patient compared with the HTLV–I carrier.
  • Fibrous change in LSG was prominent in the HAM–SS patient.
  • Although TGF–β expression was similar in the two patients, expression of HTLV–I–related proteins including p12, p28, group–specific antigen (GAG), and nuclear factor kappa–B (NF–κB) in the LSG were dominantly detected in the HAM–SS patient.
  • Frequency of TGF–β staining in HTLV–I–seropositive SS patients without ACA, HTLV–I–seronegative SS patients with ACA, and HTLV–I–seronegative SS patients without ACA was lower than that of the previous two patients.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

1 Possible association between vitamin D deficiency and restless legs syndrome Full Text Neuropsychiatric Disease and Treatment, June 6, 2014    Free full text    Clinical Article

2 Chronic idiopathic axonal polyneuropathy and vitamin B6: a controlled population-based study Journal of the Peripheral Nervous System, June 6, 2014    Clinical Article

3 Pathology residency training: time for a new paradigm Human Pathology, March 25, 2014    Clinical Article

4 Systemic sclerosis: Comparison of efficacy of oral cyclophosphamide and azathioprine on skin score and pulmonary involvement--a retrospective study Rheumatology International, May 8, 2014    Clinical Article

5 Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives The Lancet, June 20, 2014    Review Article    Clinical Article

6 Nuts in the prevention and treatment of metabolic syndrome American Journal of Clinical Nutrition, June 5, 2014    Review Article

7 Nut consumption and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 4, 2014    Evidence Based Medicine    Review Article

8 Foreign-trained physicians frustrated at lack of residency positions, “brain waste,” when they move to higher-income countries, new study finds St. Michael's Hospital, June 27, 2014

9 Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: Results from the International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome American Journal of Psychiatry, June 18, 2014    Clinical Article

10 Low vitamin D as a risk factor for the development of myalgia in patients taking high-dose simvastatin: A retrospective review Clinical Therapeutics, April 17, 2014    Review Article

11 Vitamin D status and Parkinson's disease: A systematic review and meta-analysis Neurological Sciences, June 5, 2014    Review Article

12 Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis American Journal of Clinical Nutrition, June 19, 2014    Evidence Based Medicine    Review Article

13 Sugar sweetened beverages consumption and risk of coronary heart disease: A meta-analysis of prospective studies Atherosclerosis, April 11, 2014    Evidence Based Medicine    Review Article

14 Calcium supplement intake and risk of cardiovascular disease in women Osteoporosis International, May 13, 2014    Clinical Article

15 Fish consumption, sleep, daily functioning, and heart rate variability Journal of Clinical Sleep Medicine, June 12, 2014    Clinical Article

16 Vitamin D supplementation and lipid profile: what does the best available evidence show Atherosclerosis, May 19, 2014    Evidence Based Medicine

17 Dance therapy in patients with chronic heart failure: A systematic review and a meta-analysis Clinical Rehabilitation, June 3, 2014    Evidence Based Medicine    Review Article

18 Fruits and vegetables consumption and risk of stroke Stroke, May 28, 2014    Evidence Based Medicine

19 Vitamin D supplements and cancer incidence and mortality: a meta-analysis British Journal of Cancer, June 12, 2014    Evidence Based Medicine

20 Effects of habitual coffee consumption on cardiometabolic disease, cardiovascular health, and all-cause mortality The Journal of Emergency Medicine, June 12, 2014    Clinical Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close