Gastric Acid Suppression and Clostridium difficile Infection: Is There a Causal Connection

Clinical Gastroenterology and Hepatology , 04/24/2012

The authors performed a meta–analysis to evaluate the association between proton pump inhibitor (PPI) therapy and the risk of Clostridium difficile infection (CDI) and found a 2–fold increase in the risk of CDI in patients using PPIs.

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