Hypoalbuminaemia, systemic albumin leak and endothelial dysfunction in peritoneal dialysis patients
Nephrology Dialysis Transplantation, Exclusive Author Commentary

Yu Z et al. – This exploratory analysis indicates that endothelial barrier function is decreased in peritoneal dialysis patients and is associated with diabetic status and markers of platelet activation more than inflammation. In contrast, hypoalbuminaemia is associated more with inflammation and atherosclerotic disease indicating a more complex relationship between systemic endothelial barrier function, inflammation and hypoalbuminaemia.

In this study we wanted to explore the relationship between systemic protein leak, inflammation and endothelial dysfunction as hypoalbuminaema remains a significant problem in peritoneal dialysis patients. We confirmed previous findings that hypoalbuminaemia was associated with inflammation whereas the systemic protein leak was more associated with markers of platelet activation. The daily leak of albumin from the circulation far exceeds the losses from the peritoneal cavity but is presumably recirculated explaining why it has less impact on the plasma albumin concentration. To solve the problem of hypoalbuminaemia in PD patients - which contributes to their tissue oedema problems - it will be necessary to target the supression of albumin synthesis associated with inflammation.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More