mdlinx mdlinx
Latest (496) Full Text Articles (11295) Article Summary

Anti-TNF therapy is associated with decreased imaging and radiation exposure in patients with Crohns disease
Inflammatory Bowel Disease,  Clinical Article

Patil SA et al. – Initiation of anti–TNF therapy for treatment of Crohn's disease (CD) is associated with a significant reduction in diagnostic radiation exposure. Conversely, steroid treatment does not reduce diagnostic radiation exposure.

Methods
  • The authors conducted a retrospective review of 99 CD patients initiated on anti-TNF therapy or corticosteroids between 2004 and 2009 in a tertiary care center.

Results
  • Sixty-five patients were initiated on anti-TNF agents and 34 were initiated on corticosteroids.
  • The anti-TNF cohort was significantly younger at diagnosis and at the time of initiation of anti-TNF or steroid therapy.
  • The anti-TNF group had significantly more stricturing, penetrating, and perianal disease than the corticosteroid group.
  • The anti-TNF cohort had a significant reduction in number of radiologic exams (5.5 vs. 3.7, P<0.01) as well as a significant reduction in the cumulative radiation dose (28.1 vs. 15.0 mSv, P<0.01) the year after initiation of therapy.
  • This reduction was largely attributable to decreased use of computed tomography (CT) scans.
  • In contrast, there was no significant change in radiation exposure in the corticosteroid cohort.
  • Logistic regression analysis showed a strong trend toward higher exposure in patients with complicated disease behavior (stricturing or penetrating phenotype) (odds ratio [OR] 2.87, 95% confidence interval [CI] 0.98-8.38).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

Last month's top read Top Articles of 2013

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Other Topics in Medical Student

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close