Improvement of arterial stiffness by reducing oxidative stress damage in elderly hypertensive patients after 6 months of atorvastatin therapy
The Journal of Clinical Hypertension, 04/25/2012
Wang J et al. – These findings suggest that atorvastatin can improve arterial stiffness possibly by reducing oxidative stress levels in elderly hypertensive patients.Methods
- A total of 73 elderly hypertensive patients were enrolled to receive atorvastatin for 6 months.
- Brachial–ankle pulse wave velocity (baPWV) and circulating biomarkers were measured before and after the intervention.
- After 6 months of treatment, the patients experienced a 19.66% reduction in low–density lipoprotein cholesterol (2.90±0.58 vs 2.33±0.56 mmol/L, P<.01) and a 10.63% reduction in baPWV (2100.89±513.21 vs 1877.56±432.06 cm/s, P=.01).
- In addition, a 21.79% reduction in circulating N–(epsilon)–carboxymethyl–lysine and a 20% reduction in Von Willebrand factor level were observed after treatment.
- Meanwhile, the activity of copper/zinc–containing superoxide dismutase (Cu/Zn SOD) was increased by 26.64% (5.04±1.01 vs 6.87±1.83 U/L, P<.001).
- Correlation analysis demonstrated that the increase of Cu/Zn SOD activity was related to the reductions of arterial stiffness (r=–0.340, P=.003).