Retrieval of serum infliximab level by shortening the maintenance infusion interval is correlated with clinical efficacy in Crohns disease
Inflammatory Bowel Disease,  Clinical Article

Hibi T et al. – A treatment strategy with an option of shortening the dosing interval of infliximab retrieves its trough level and may be useful for maintaining its efficacy.

  • This was an open–label prospective multicenter study.
  • Infliximab was administered at 5 mg/kg to patients with active CD at weeks 0, 2, and 6.
  • Week 10 responders received infliximab every 8 weeks thereafter.
  • In those with loss of response after week 14 the interval was switched to every 4 weeks.
  • Co–primary endpoints were the rate of patients achieving clinical response and remission at week 54.
  • Serum level of infliximab was measured at each visit.

  • Fifty–seven patients who responded to induction treatment received maintenance therapy after week 14.
  • Thirty–seven patients continued at the 8–week interval and 20 patients were switched to a 4–week interval.
  • The overall clinical response and remission rates at week 54 were 82.5% and 61.4%, respectively.
  • For those with loss of response, treatment at the 4–week interval resulted in clinical response and remission rates of 83.3% (15/18) and 55.6% (10/18), respectively, at week 54.
  • A correlation between clinical efficacy and serum trough level was found (P < 0.01, overall).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More