Wagner S et al. – The authors revealed significant executive dysfunctions in patients with unipolar, non–psychotic major depressive disorder compared with healthy controls and an improvement of the Stroop performance during the course of treatment.Methods
- Meta–analytic methods were used to assess the severity of executive dysfunctions in unipolar, non–psychotic MDD as compared to healthy controls and to investigate their course during antidepressant treatment.
- Fifteen studies comparing the executive functions of 375 patients with DSM–IV MDD and 481 healthy controls were analysed.
- Furthermore, in three studies, including 122 patients with MDD, the Stroop test performance was examined before and after antidepressant treatment.
- Patients with MDD performed 0.439 up to 1.18 (P < 0.0001) standard mean differences worse than healthy controls.
- The Stroop performance improved during the course of treatment (P = 0.0001).