Smartest Doc
Evaluation of oxidative stress in children with congenital heart defects
Pediatrics International, 04/30/2012
Pirinccioglu AG et al. – Oxidative stress and its association with other markers in children with congenital heart disease (CHD) was established. To the best of knowledge, this is the first time that protein carbonyl (PCO) has been used as a biomarker in CHD and it may be employed as a new diagnostic biomarker in CHD and in the assessment of its severity.
Methods- The study involves measurements of malondialdehyde (MDA), protein carbonyl (PCO), total anti-oxidant capacity, high-sensitive C-reactive protein (hs-CRP), fibrinogen and cytokine levels in 43 children with CHD and 30 healthy age-matched children.
- MDA, PCO, hs-CRP, fibrinogen, IL-6 and tumor necrosis factor-alpha were significantly elevated while total anti-oxidant capacity was significantly declined in patients compared with the controls.
- MDA was positively correlated with PCO, hs-CRP, Qp/Qs and systolic pulmonary artery pressure. PCO was positively correlated with hs-CRP, fibrinogen, IL-6 and systolic pulmonary artery pressure.
