Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma
International Journal of Cancer, 05/03/2012
Sperveslage J et al. – The study revealed strong evidence that lack of CCR7 impairs the metastatic potential of pancreatic ductal adenocarcinoma (PDAC). Lymph vessel invasion by CCR7 expressing PDAC cells may be additionally enhanced by upregulation of CCL21 in tumor–associated lymph vessels, representing a previously unknown factor of lymphatic spread.