Familial Adult Myoclonic Epilepsy: Recognition of Mild Phenotypes and Refinement of the 2q Locus

JAMA Neurology, 04/27/2012

The most common Familial adult myoclonic epilepsy (FAME) phenotype in this large family is mild postural hand tremor resembling essential tremor, combined with subtle proximal myoclonus. Generalized tonic–clonic seizures are uncommon and occur around sleep onset following severe generalized myoclonus.

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