Clinical features and prognostic factors in patients with carcinomatous meningitis secondary to breast cancer

The Breast Journal, 04/24/2012

According to multivariate analysis, patients were divided into favorable and poor prognostic groups, with OS of 14 weeks and 2 weeks, respectively (p < .001). These factors can identify a subgroup of patients who are candidates for an intensive management approach.

Methods

  • The purpose of this study was to describe a series of patients with breast cancer–associated CM to determine the clinical features and prognostic factors associated with survival.
  • Authors conducted a retrospective study on 49 patients diagnosed between January 2003 and December 2007 at the Instituto Nacional de Cancerología in Mexico City. CSF cytopathology samples were re–reviewed to confirm the diagnosis.

Results

  • Overall survival (OS) for patients with breast cancer with CM was 7 weeks.
  • Factors independently associated with better OS included absence of encephalopathy at diagnosis (11 weeks versus 1 week; p = .036), low CSF protein content (15 versus 5 weeks; p = .022), and nontriple–negative receptor status in the primary breast cancer tumor (13 versus 3 weeks; p = .015).

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