Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Gastroenterology, 04/20/2012
Kanda M et al. – The authors show that more than 99% of the earliest–stage, lowest–grade, pancreatic intraepithelial neoplasm–1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve the understanding of the development and progression of these premalignant lesions.



