Anti-tumor necrosis factor and postoperative complications in Crohns disease: systematic review and meta-analysis
Inflammatory Bowel Disease,  Clinical Article

Kopylov U et al. – Preoperative infliximab treatment is associated with an increased risk of postoperative infectious complications, mostly nonlocal. A trend toward an increased risk of noninfectious and overall complications was also observed.

Methods
  • A systematic review and meta-analysis of comparative cohort studies was performed assessing postoperative complication rates in CD patients who were treated with anti-TNF antibodies within 3 months before surgery versus patients who were not.
  • The primary outcome was overall complication rate within 1 month of surgery.
  • Secondary outcomes included the rate of infectious and noninfectious complications.
  • The quality of studies was assessed based on selection of patients and controls, comparability of the study groups, and assessment of outcomes.
  • Odds ratios (OR) with 95% confidence intervals (CIs) were computed.

Results
  • A total of eight studies including 1641 patients were included in the meta-analysis.
  • Preoperative infliximab therapy in CD patients undergoing abdominal surgery was associated with a trend toward an increased rate of total complications (OR 1.72, 95% CI, 0.93-3.19).
  • Anti-TNF treatments were associated with a modestly increased risk of infectious complications (OR 1.50, 95% CI 1.08-2.08), mostly remote from the surgical site (OR 2.07 95% CI 1.30-3.30) and with a trend toward a higher rate of noninfectious complications (OR 2.00, 95% CI 0.89-4.46).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...

Your Unread Messages in Medical Student

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Medical Student Articles

1 Effect of pentoxifylline on renal function and urinary albumin excretion in patients with diabetic kidney disease: The PREDIAN trial Journal of the American Society of Nephrology, June 30, 2014    Clinical Article

2 Regular fish consumption and age-related brain gray matter loss American Journal of Preventive Medicine, August 15, 2014    Clinical Article

3 Blood pressure in relation to coffee and caffeine consumption Current Hypertension Reports, August 8, 2014    Review Article

4 Egg consumption is associated with increased risk of ovarian cancer: Evidence from a meta-analysis of observational studies Clinical Nutrition, August 5, 2014    Evidence Based Medicine

5 Coffee consumption and mortality from all causes, cardiovascular disease, and cancer: a dose-response meta-analysis American Journal of Epidemiology, August 26, 2014    Evidence Based Medicine    Review Article

6 Radiography students clinical placement experiences in MRI: A phenomenological study Radiography, August 4, 2014    Clinical Article

7 Meta-analysis of black tea consumption and breast cancer risk: update 2013 Nutrition and Cancer, August 6, 2014    Evidence Based Medicine

8 Vitamin D and sleep disorders Full Text Nature and Science of Sleep, August 13, 2014    Free full text    Clinical Article

9 Yogurt consumption, weight change and risk of overweight/obesity: The SUN cohort study Nutrition, Metabolism & Cardiovascular Diseases, July 28, 2014    Clinical Article

10 Failure mode and effects analysis of the universal anaesthesia machine in two tertiary care hospitals in Sierra Leone British Journal of Anesthesia, August 19, 2014    Clinical Article

11 A very low carbohydrate, low saturated fat diet for Type 2 diabetes management: A randomized trial Diabetes Care, August 7, 2014    Clinical Article

12 Sweetened carbonated beverage consumption and cancer risk: Meta-analysis and review European Journal of Cancer Prevention, August 1, 2014    Evidence Based Medicine    Review Article

13 Possible association between vitamin D deficiency and restless legs syndrome Full Text Neuropsychiatric Disease and Treatment, June 6, 2014    Free full text    Clinical Article

14 Vitamin D and the risk of dementia and Alzheimer's disease Neurology®, August 27, 2014    Clinical Article

15 Impact of dairy consumption on essential hypertension: A clinical study Full Text Nutrition Journal, August 29, 2014    Free full text    Clinical Article

16 High protein weight loss diets in obese subjects with type 2 diabetes mellitus Nutrition, Metabolism & Cardiovascular Diseases, January 3, 2014    Clinical Article

17 Maternal prepregnancy folate intake and risk of spontaneous abortion and stillbirth Obstetrics and Gynecology, July 3, 2014    Clinical Article

18 Nut consumption and the risk of coronary artery disease: A dose–response meta-analysis of 13 prospective studies Thrombosis Research, August 14, 2014    Clinical Article

19 Fruit and vegetable consumption and mortality from all causes, cardiovascular disease, and cancer: systematic review and dose-response meta-analysis of prospective cohort studies BMJ, August 1, 2014    Evidence Based Medicine    Review Article    Clinical Article

20 Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis American Journal of Clinical Nutrition, August 11, 2014    Evidence Based Medicine    Review Article

Indexed Journals in Medical Student: Academic Medicine, BMC Medical Education, Medical Teachermore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close