Tick-Borne Encephalitis Virus-Neutralizing Antibodies in Different Immunoglobulin Preparations
Clinical and Vaccine Immunology, 03/30/2012
Exclusive author commentary
Rabel PO et al. – Patients with primary immunodeficiency (PIDs) depend on the presence of a variety of antibody specificities in intravenous immunoglobulin (IVIG). Using the tick–borne encephalitis virus (TBEV), geographic variability in IVIG antibody content was shown. Care should therefore be exercised when treating PIDs in a given geography, as only locally sourced plasma contains the antibody specificities against the circulating pathogens in the given locality.
Thomas R. Kreil (04/02/2012) comments:
Further evidence for the geographic variability in IVIG antibody content has been demonstrated recently for Hepatitis A virus (Farcet et al.,2010), West Nile Virus (Rabel et al., 2011; Planitzer et al., 2009), Cytomegalovirus (Planitzer et al., 2011) and the different Echovirus serotypes (Planitzer et al., 2011).