A diet, physical activity, and stress reduction intervention in men with rising prostate-specific antigen after treatment for prostate cancer
Cancer Epidemiology,  Clinical Article

Hebert JR et al. – Results are discussed in the context of conventional treatment strategies that were more aggressive when this study was being conducted in the mid–2000s. Positive health changes in a number of lifestyle parameters were observed with the intervention, and both increased fruit and reduced saturated fat intakes were associated with maintaining PSA levels in men with biochemically recurrent disease.

Methods
  • A randomized trial of an intensive diet, physical activity, and meditation intervention was conducted in men with rising post-treatment PSA after definitive treatment for PrCA.
  • Intention-to-treat methods were used to compare usual care to the intervention in 47 men with complete data.
  • Signal detection methods were used to identify dietary factors associated with PSA change.

Results
  • The intervention and control groups did not differ statistically on any demographic or disease-related factor.
  • Although the intervention group experienced decreases of 39% in intakes of saturated fatty acid (SFA as percent of total calories) (p<0.0001) and 12% in total energy intake (218kcal/day, p<0.05)], no difference in PSA change was observed by intervention status.
  • Signal detection methods indicated that in men increasing their consumption of fruit, 56% experienced no rise in PSA (vs. 29% in men who did not increase their fruit intake).
  • Among men who increased fruit and fiber intakes, PSA increased in 83% of participants who also increased saturated fatty acid intake (vs. 44% in participants who decreased or maintained saturated fatty acid intake).

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