Lymphotropic hepatitis C virus has an interferon-resistant phenotype

Journal of Viral Hepatitis, 03/29/2012

Genotype 1 and the presence of one or no mutations in the IFN–sensitivity determining region were associated with higher levels of B–cell HCV RNA. B–cell–tropic HCV appears to have an IFN–resistant phenotype. B–cell HCV RNA positivity is a predictive factor for resistance to IFN–based therapy.

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