Vitamin D Insufficiency Is Associated With Diabetes Risk in Native American Children
Clinical Pediatrics, 02/10/2012
Nsiah–Kumi PA et al. – Vitamin D insufficiency was nearly universal in this cohort of NA children and was associated with diabetes and vascular risk markers. Whether vitamin D supplementation can improve insulin resistance must be studied further.Methods
- In a cross–section of NA children 5 to 18 years old (N = 198), anthropometrics, biomarkers of insulin resistance, and 25–hydroxy–vitamin D concentration [25(OH) vitamin D] were measured.
- BMI% and homeostatic model assessment of insulin resistance (HOMA–IR) were calculated.
- Mean age was 10.8 ± 0.3 years (mean ± SEM).
- Mean serum 25(OH) vitamin D was 17.8 ± 0.4 ng/mL and 97% had vitamin D insufficiency [25(OH) vitamin D <30 ng/mL].
- After adjusting for BMI, 25(OH) vitamin D was inversely associated with HOMA–IR (P < .0001) and several other markers of insulin resistance.