Milk, dairy intake and risk of endometrial cancer: A twenty six-year follow-up
International Journal of Cancer, 07/05/2011
Davaasambuu G et al. – Authors observed a marginally significant overall association between dairy intake and endometrial cancer and a stronger association among postmenopausal women who were not using estrogen–containing hormones.Methods
- Prospective cohort study
- 68,019 female participants in the Nurses' Health Study aged 34–59 in 1980
- Milk and dairy consumption were assessed in 1980, 1984, 1986, 1990, 1994, 1998, and 2002 as servings per day and the follow–up continued through 2006.
- The multivariate relative risks of adenocarcinoma of the endometrium across categories of cumulatively averaged total dairy consumption compared with < 1 svg/d were: 0.94 (95% CI 0.71–1.25) for 1–1.4 svg/day, 1.14 (0.87–1.49) for 1.5–1.9 svg/day, 1.10 (0.84–1.44) for 2–2.9 svg/day, 1.26 (0.94–1.70) for 3 svg/day) (p for trend= 0.06).
- The association between total dairy intake and endometrial cancer was significant only among the post–menopausal women (for 3 svg/day RR = 1.41, 95% CI 1.01– 1.98, p for trend=0.02) and was evident only among those who were not currently using hormone therapy (RR = 1.58, 95% CI 1.05–2.36, p for trend=0.003).
- Total dairy intake was not significantly associated with risk of pre–invasive endometrial cancer.