Relationship of maternal vitamin D level with maternal and infant respiratory disease
American Journal of Obstetrics and Gynecology, 04/15/2011
Carroll KN et al. – Higher maternal vitamin D levels were associated with decreased odds of asthma.Methods
- Cross-sectional analyses of 340 mother-infant dyads enrolled September-May 2004-2008 during an infant viral respiratory infection.
- Maternal vitamin D levels were determined from enrollment blood specimens.
- At enrollment, self-reported maternal asthma and infant respiratory infection severity using a bronchiolitis score was determined.
- The association of maternal vitamin D levels and maternal asthma and infant bronchiolitis score in race-stratified multivariable regression models was assessed.
- The cohort was 70% White, 19% African-American, and 21% had asthma.
- The median maternal vitamin D level was 20 ng/ml (Interquartile range 14,28).
- Among White women, a 14 ng/ml increase in vitamin D was associated with decreased odds of asthma (AOR 0.54, 95% CI 0.33-0.86).
- Maternal vitamin D was not associated with infant bronchiolitis score.