ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion

Cardiovascular Diabetology, 06/14/2012

Treatment with the Rho/ROCK pathway inhibitor fasudil attenuated HG–induced monocyte–endothelial cell adhesion, possibly by reducing endothelial expression of VCAM–1 and MCP–1. These results suggest inhibition of Rho/ROCK signaling may have therapeutic potential in preventing diabetes associated vascular inflammation and atherogenesis.

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